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Propofol

Propofol-Lipuro B. Braun Melsungen, Propofol Mct Baxter, Propofol Mit Mct Fresenius · ATC code N01AX10

Brand names: Disoprivan, Propofol Baxter, Propofol Bioq Pharma, Propofol Farmak, Propofol Fresenius, Propofol-Lipuro B. Braun Melsungen, Propofol Mct Baxter, Propofol Mct Fresenius, Propofol Mit Mct Fresenius, Centropol, Paisofol

Key facts
Active substance
Propofol
ATC code
N01AX10
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-11-06

Key facts

Propofol is a short-acting intravenous hypnotic in a lipid emulsion. Per the US label it is used for induction and maintenance of general anaesthesia, procedural (MAC) sedation and ICU sedation of ventilated adults.

What it is used for

  • Induction of general anaesthesia from 3 years of age; maintenance from 2 months of age
  • Initiation and maintenance of monitored anaesthesia care (MAC) sedation in adults, and sedation with regional anaesthesia
  • ICU sedation of intubated, mechanically ventilated adults (not paediatric ICU sedation)

Dosing

  • Induction, adults under 65 years (ASA-PS I or II): 2 mg/kg to 2.5 mg/kg titrated to effect; elderly, debilitated or ASA-PS III or IV: about 1 mg/kg to 1.5 mg/kg, no rapid bolus
  • Induction, children 3 years through 16 years: 2.5 mg/kg to 3.5 mg/kg
  • Maintenance in adults: 100 mcg/kg/min to 200 mcg/kg/min with nitrous oxide, reduced 30% to 50% during the first half-hour
  • MAC sedation: usually 25 mcg/kg/min to 75 mcg/kg/min after slow initiation
  • ICU sedation: start at 5 mcg/kg/min, increase by 5 mcg/kg/min to 10 mcg/kg/min at least 5 minutes apart; usual maintenance 5 mcg/kg/min to 50 mcg/kg/min; do not exceed 4 mg/kg/hour unless benefits outweigh risks
  • Strict asepsis: use within 12 hours of opening and discard tubing and remainder after 12 hours

Contraindications

  • Hypersensitivity to propofol or any component
  • History of anaphylaxis to eggs, egg products, soybeans or soy products

Important warnings

  • Only by staff trained in anaesthesia, with airway, ventilation and resuscitation equipment at hand; hypotension, apnoea and desaturation are more likely after rapid bolus
  • Propofol infusion syndrome in ICU sedation (metabolic acidosis, hyperkalaemia, rhabdomyolysis, renal and cardiac failure), sometimes fatal
  • Bradycardia, asystole and rarely cardiac arrest (no vagolytic activity), especially in children given fentanyl
  • Fatal and life-threatening anaphylactic reactions; seizure risk in epileptic patients during recovery
  • Microbial contamination of the emulsion if asepsis is not maintained

Side effects

  • Hypotension, bradycardia, arrhythmias
  • Apnoea, cough, upper airway obstruction, hypoventilation
  • Movement, hypertonia, agitation, abnormal dreams
  • Nausea, hypersalivation; injection-site pain
  • ICU: hyperlipidaemia, decreased cardiac output

Interactions

  • Opioids, benzodiazepines and other sedatives: lower induction dose and greater falls in blood pressure and cardiac output
  • Fentanyl in children: serious bradycardia
  • Inhalational agents and nitrous oxide increase anaesthetic and cardiorespiratory effects
  • Valproate: higher propofol levels; reduce the propofol dose

Pregnancy and breastfeeding

  • Decades of data, mostly at caesarean delivery, show no drug-associated risk of major birth defects or miscarriage; neonatal depression reported after exposure during delivery
  • Present in human milk; no adverse reactions shown in breastfed infants

Summary of the official product information, written with AI on 2026-11-14. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Germany

  • DisoprivanAspen Pharma Trading Limited · 1 register entry
  • Propofol BaxterBaxter Holding B.V. · 1 register entry
  • Propofol Bioq PharmaBioq Pharma B.V. · 1 register entry
  • Propofol FarmakAspire Pharma (Malta) Limited · 1 register entry
  • Propofol FreseniusFresenius Kabi Deutschland Gmbh · 1 register entry
  • Propofol-Lipuro B. Braun MelsungenB.Braun Melsungen Ag · 1 register entry
  • Propofol Mct BaxterBaxter Holding B.V. · 1 register entry
  • Propofol Mct FreseniusFresenius Kabi Deutschland Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-11-06

Austria

  • Propofol-Lipuro B. Braun MelsungenB.Braun Melsungen Ag · 1 register entry
  • Propofol Mct BaxterBaxter Holding B.V. · 1 register entry
  • Propofol Mit Mct FreseniusFresenius Kabi Austria Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-11-06

Turkey

  • CentropolCENTURİON İLAÇ SAN. VE TİC. A.Ş. · 3 register entries
  • PaisofolAROMA İLAÇ SAN. LTD. ŞTİ. · 1 register entry
  • PropofolİDE İLAÇ RUHSATLANDIRMA BİYOFARMASÖTİK DANIŞMANLIK EĞİTİM VE MÜMESSİLLİK HİZMETLERİ DIŞ TİCARET İTHALAT İHRACAT LTD. ŞTİ., ADEKA İLAÇ SAN. VE TİC. A.Ş., HAVER FARMA İLAÇ A.Ş., VEM İLAÇ SAN. VE TİC. A.Ş., POLİFARMA İLAÇ SAN. VE TİC. A.Ş. · 16 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-11-06

Brand names in 27 more European countries
Belgium
Diprivan, Propofol B. Braun, Propolipid
Bulgaria
Propofol Mct/Lct Fresenius, Пропофол-Липуро B. Braun Melsungen, Пропофол Пф, Пропофол Ромфарм, Профол
Croatia
Propofol-Lipuro B. Braun Adria, Propofol Mct Fresenius
Cyprus
Hiremon, Propofol-Lipuro B. Braun Melsungen, Propofol Mct/Lct Fresenius
Czechia
Anesia Baxter, Propofol Baxter, Propofol-Lipuro B. Braun Melsungen, Propofol Mct Fresenius, Propofol Mct/Lct Fresenius
Denmark
Profast, Propofol B. Braun, Propolipid
Estonia
Anesia, Propofol-Lipuro B. Braun Melsungen, Propoven
Finland
Profast, Propofol-Lipuro B. Braun Melsungen, Propolipid
France
Diprivan, Propofol Baxter, Propofol Bioq, Propofol Kabi, Propofol Lipuro B Braun Melsungen
Greece
Hiremon, Propofol Baxter, Propofol-Lipuro B. Braun Melsungen, Propofol Mct/Lct /Fresenius, Propofol Mct/Lct Fresenius
Hungary
Anesia, Propofol Mct Fresenius, Propofol Mct/Lct Fresenius
Iceland
Propolipid
Ireland
Diprivan, Propofol
Italy
Diprivan, Propofol B. Braun, Propofol Kabi, Rapiva, Ripol, Unifol
Latvia
Anesia, Propofol-Lipuro B. Braun Melsungen, Propoven
Lithuania
Anesia, Propofol-Lipuro B. Braun Melsungen, Propoven
Luxembourg
Diprivan, Propofol Baxter, Propofol-Lipuro B. Braun Melsungen, Propolipid
Malta
Propofol
Netherlands
Diprivan-10, Diprivan-20, Propofol Baxter, Propofol Bioq Pharma, Propofol-Lipuro B. Braun Melsungen, Propofol-Lipuro B.Braun Melsungen, Propofol Mct/Lct Fresenius, Propofol Spiva
Norway
Profast, Propofol-Lipuro B. Braun Melsungen, Propolipid
Poland
Diprivan, Plofed, Propofol Baxter, Propofol Farmak, Propofol-Lipuro B. Braun Melsungen, Propofol Mct/Lct Fresenius
Portugal
Propofol Baxter, Propofol Demo, Propofol Fresenius, Propofol-Lipuro B. Braun Melsungen, Propofol Mct/Lct Fresenius
Romania
Profast, Propofol-Lipuro B.Braun Melsungen, Propofol Mct/Lct Fresenius, Propofol Rompharm
Slovakia
Propofol-Lipuro B. Braun Melsungen, Propofol Mct Fresenius, Propofol Mct/Lct Fresenius
Slovenia
Anesia, Propofol Baxter, Propofol-Lipuro B. Braun Melsungen, Propoven
Spain
Diprivan, Propofol Baxter, Propofol Farmak, Propofol Lipoven Fresenius, Propofol Lipuro B. Braun Melsungen
Sweden
Diprivan, Profast, Propofol-Lipuro B. Braun Melsungen, Propofol Sandoz, Propolipid

EMA – Article 57 product data (EU/EEA), 2026-11-06

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

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Sources

  1. U.S. Food and Drug Administration. Propofol (Civica, Inc) – Prescribing Information, 2026-09-18. DailyMed (NLM), 2026-11-06. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9ba70032-40c2-41c5-9f99-d1f94032d3dc
  2. EMA – Article 57 product data (EU/EEA), 2026-11-06. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-11-06. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-11-06. https://www.titck.gov.tr/dinamikmodul/85

Editorial: Medelix editorial team · last updated 2026-11-06 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.