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Adrenaline

Adrenalin Aguettant, Adrenalin Noridem, Anapen, Epipen · ATC code C01CA24

Also known as: Adrenalin, Adrenalina, Adrénaline · Brand names: Adrenalin Aguettant, Adrenalin Ethypharm, Anapen, Epinephrin Bradex, Fastjekt, Adrenalin Noridem, Epipen, L-Adrenalin Spritzfertig Fresenius, Deva Adrenalin, Penepin

Key facts
Active substance
Adrenaline
Drug class
Butyroxan
ATC code
C01CA24
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-11-06

Key facts

Adrenaline (epinephrine) is a catecholamine acting on alpha- and beta-adrenergic receptors. Per the US label the 1 mg/mL injection is used for anaphylaxis and for hypotension associated with septic shock.

What it is used for

  • Emergency treatment of allergic reactions (Type I), including anaphylaxis
  • Hypotension associated with septic shock in adults, to increase mean arterial pressure

Dosing

  • Anaphylaxis, adults and children 30 kg or more: 0.3 to 0.5 mg (0.3 mL to 0.5 mL) undiluted, intramuscularly or subcutaneously into the anterolateral thigh; maximum 0.5 mg per injection
  • Children less than 30 kg: 0.01 mg/kg (0.01 mL/kg) undiluted into the anterolateral thigh
  • Repeat every 5 to 10 minutes as necessary; do not inject repeatedly at the same site
  • Septic shock: 1 mg in 1,000 mL of a 5% dextrose-containing solution (1 mcg/mL); infuse 0.05 mcg/kg/min to 2 mcg/kg/min, titrated to mean arterial pressure
  • Adjust every 10 - 15 minutes in increments of 0.05 mcg/kg/min to 0.2 mcg/kg/min; wean gradually after stabilisation, preferably into a large vein

Contraindications

  • None stated in the label

Important warnings

  • Hypertension with intravenous use: titrate with monitoring of vital signs; invasive arterial and central venous pressure monitoring recommended
  • Extravasation can cause tissue necrosis; infiltrate the area with 10 mL to 15 mL of saline containing 5 mg to 10 mg of phentolamine
  • Anaphylaxis: inject into the anterolateral thigh; not into the buttock, digits, hands or feet
  • Pulmonary oedema, arrhythmias and angina, especially in coronary or organic heart disease
  • Rare serious soft-tissue infections (including Clostridia) at the injection site

Side effects

  • Anxiety, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor
  • Nausea, vomiting, headache, respiratory difficulties
  • Tachyarrhythmias, hypertension, myocardial ischaemia; cerebral haemorrhage with rapid blood pressure rises
  • With infusion: hyperglycaemia, hypokalaemia, lactic acidosis, limb ischaemia, renal insufficiency

Interactions

  • Pressor effect reduced by alpha-blockers, vasodilators (e.g. nitrates), diuretics, antihypertensives, ergot alkaloids
  • Pressor effect increased by sympathomimetics, beta-blockers, tricyclic antidepressants, MAO and COMT inhibitors, clonidine, doxapram, oxytocin
  • Arrhythmia risk with beta-blockers, halogenated anaesthetics, antihistamines, thyroid hormones, cardiac glycosides, quinidine
  • Do not use to treat hypotension caused by phenothiazines

Pregnancy and breastfeeding

  • Decades of use show no drug-associated risk of major birth defects or miscarriage; anaphylaxis is treated as in non-pregnant patients
  • Avoid during the second stage of labour and in obstetrics when maternal blood pressure exceeds 130/80 mmHg; may cause uterine atony with haemorrhage

Summary of the official product information, written with AI on 2026-11-14. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

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For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Germany

  • Adrenalin AguettantLaboratoire Aguettant · 1 register entry
  • Adrenalin EthypharmEthypharm · 1 register entry
  • AnapenBioprojet Pharma · 2 register entries
  • Epinephrin BradexBradex S.A. · 1 register entry
  • FastjektViatris Healthcare Gmbh · 2 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-11-06

Austria

  • Adrenalin AguettantLaboratoire Aguettant · 1 register entry
  • Adrenalin NoridemNoridem Enterprises Ltd · 1 register entry
  • AnapenBioprojet Pharma · 2 register entries
  • EpipenViatris Healthcare Limited, Viatris Austria Gmbh · 4 register entries
  • L-Adrenalin Spritzfertig FreseniusFresenius Kabi Austria Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-11-06

Turkey

  • AdrenalinDROGSAN İLAÇLARI SAN. VE TİC. A.Ş., GALEN İLAÇ SAN.VE TİC.A.Ş, BİOFARMA İLAÇ SAN. VE TİC. A.Ş., ALTOBİO İLAÇ LTD. ŞTİ., OSEL İLAÇ SAN. VE TİC. A.Ş. · 30 register entries
  • Deva AdrenalinDEVA HOLDİNG A.Ş. · 1 register entry
  • PenepinVEM İLAÇ SAN. VE TİC. A.Ş. · 4 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-11-06

Brand names in 28 more European countries
Belgium
Adrenaline (Tartrate) Aguettant, Adrenaline (Tartrate) Bradex, Adrenaline Sterop, Epipen
Bulgaria
Адреналин Софарма, Епипен Н
Croatia
Epipen, Orduxato
Cyprus
Anapen, Epipen Jr. Twist, Epipen Junior, Epipen Twist
Czechia
Adrenalin Bradex, Adrenaline Accord, Anapen, Epipen
Denmark
Adrenalin Aguettant, Adrenalin Bradex, Adrenalin Martindale Pharma, Adrenalin Sad, Adrenaline Ethypharm, Anapen, Epipen
Estonia
Adrenaline Auxilia, Epipen, Pulsina
Finland
Adrenalin Aguettant, Adrenalin Ethypharm, Adrenalin Evolan Pharma, Adrenalin Martindale Pharma, Adrenalin Noridem, Anapen, Epinadren, Epipen
France
Adrenaline Accord, Adrenaline Aguettant, Adrenaline Bradex, Adrenaline Sans Sulfite Aguettant, Adrenaline Viatris, Anapen, Emerade, Epipen
Greece
Adrenaline Injection Ariti, Anapen, Epinephrine Viatris, Epipen
Hungary
Adrenalin Bradex, Adresalf, Anapen, Epipen, Tonogen
Iceland
Adrenalin Viatris, Epipen, Eurneffy
Ireland
Adrenaline (Epinephrine) Laboratoire Aguettant, Adrenaline (Epinephrine) Mercury Pharmaceuticals (Ireland), Anapen, Epipen
Italy
Adrenalina Aguettant, Adrenalina Galenica Senese, Adrenalina Monico, Adrenalina S.A.L.F., Chenpen, Epipen, Fastjekt, Pulsina
Latvia
Adrenaline Sopharma, Epipen
Liechtenstein
Eurneffy
Lithuania
Epipen, Epixust
Luxembourg
Adrenaline (Tartrate) Aguettant, Adrenaline Bradex, Adrenaline Tartrate Aguettant, Anapen, Fastjekt
Malta
Adrenalin Martindale Pharma, Adrenaline (Epinephrine) Mercury Pharmaceuticals (Ireland), Adrenalinе Sopharma, Epipen
Netherlands
Adrenaline Accord, Adrenaline Aguettant, Adrenaline Cf, Adrenaline Noridem, Anapen, Epipen
Norway
Adrenalin Aguettant, Adrenalin Ethypharm, Adrenalin Martindale Pharma, Adrenalin Noridem, Anapen, Epipen, Eurneffy
Poland
Adrenalina Aguettant, Adrenalina Noridem, Adrenalina Wzf, Epipen Jr., Epipen Senior
Portugal
Adrenalina Accord, Adrenalina Aguettant, Adrenalina Basi, Adrenalina Medlink, Adrenalina Noridem, Anapen, Epipen
Romania
Adrenalina Hypericum, Adrenalină Noridem, Adrenalină Terapia, Epipen
Slovakia
Adrenalin Bradex, Epipen
Slovenia
Anapen, Epipen
Spain
Adrenalina Aguettant, Adrenalina B. Braun, Adrenalina Basi, Adrenalina Bradex, Adrenalina Ethypharm, Adrenalina Level, Altellus Adultos, Altellus Niños, Anapen
Sweden
Adrenalin Aguettant, Adrenalin Bradex, Adrenalin Ethypharm, Adrenalin Martindale Pharma, Adrenalin Viatris, Anapen, Emerade, Epipen, Nepipe

EMA – Article 57 product data (EU/EEA), 2026-11-06

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Sources

  1. U.S. Food and Drug Administration. EPINEPHRINE (BPI Labs, LLC) – Prescribing Information, 2025-12-26. DailyMed (NLM), 2026-11-06. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3fd8dd51-0aeb-43dd-9de0-c11b0330b15e
  2. EMA – Article 57 product data (EU/EEA), 2026-11-06. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-11-06. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-11-06. https://www.titck.gov.tr/dinamikmodul/85
  5. Wikidata (CC0): ATC C01CA.

Editorial: Medelix editorial team · last updated 2026-11-06 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.