Wells score (deep vein thrombosis)
Pre-test probability of leg DVT (two-level: likely / unlikely)
- AWMF S2k VTE 2023
- Derived in Canada
Sources last checked: 2026-10-13
Wells score (deep vein thrombosis)
Pre-test probability of leg DVT (two-level: likely / unlikely)
In the Wells 2003 strategy and AWMF 2023, D-dimer is the next step: a negative result excludes DVT without ultrasound; a positive D-dimer leads to compression ultrasound.
Validated in outpatients with suspected first lower-limb DVT. It performs less well in inpatients, in suspected recurrence and in pregnancy. A three-level version (≤ 0 low, 1–2 moderate, ≥ 3 high) also exists — do not mix the two.
Interpretation
| ≤ 1 — DVT unlikely | In the Wells 2003 strategy and AWMF 2023, D-dimer is the next step: a negative result excludes DVT without ultrasound; a positive D-dimer leads to compression ultrasound. |
|---|---|
| ≥ 2 — DVT likely | In the Wells 2003 strategy and AWMF 2023, compression ultrasound is the next step; if negative, a negative D-dimer or repeat ultrasound after about a week completes the work-up. |
What is the Wells score (deep vein thrombosis)?
The Wells DVT score estimates the probability of lower-limb deep vein thrombosis from nine clinical findings and one subtractive item. In the two-level form used by Wells and colleagues in a randomised management study (NEJM 2003), patients with ≤ 1 point (DVT unlikely) and a negative D-dimer could safely forgo ultrasound. It is the score used in the German AWMF S2k guideline.
When to use it
- Outpatients or emergency patients with suspected first DVT of the leg.
- Before ordering D-dimer, to decide whether a negative result can exclude DVT.
- To prioritise compression ultrasound when access is limited.
When not to use it
- Suspected upper-limb DVT.
- Pregnancy and hospitalised patients, where performance is weaker.
- Suspected recurrent DVT in the same leg without considering prior imaging.
How it is calculated
| Criterion | Points |
|---|---|
| Active cancer (treatment ongoing, within 6 months, or palliative) | +1 |
| Paralysis, paresis or recent plaster immobilisation of the leg | +1 |
| Bedridden ≥ 3 days, or major surgery within 12 weeks (general or regional anaesthesia) | +1 |
| Localised tenderness along the deep venous system | +1 |
| Entire leg swollen | +1 |
| Calf swelling ≥ 3 cm compared with the asymptomatic side | +1 |
| Pitting oedema confined to the symptomatic leg | +1 |
| Collateral superficial veins (non-varicose) | +1 |
| Previously documented DVT | +1 |
| Alternative diagnosis at least as likely as DVT | -2 |
Clinical pearls and limitations
- Validated in outpatients with suspected first lower-limb DVT. It performs less well in inpatients, in suspected recurrence and in pregnancy. A three-level version (≤ 0 low, 1–2 moderate, ≥ 3 high) also exists — do not mix the two.
- 'Alternative diagnosis at least as likely' subtracts 2 points — the score can be negative.
- Calf circumference is measured 10 cm below the tibial tuberosity and compared with the other leg.
- Active cancer means treatment within 6 months, ongoing treatment, or palliative care.
- In AWMF 2023, the two-level score: ≥ 2 high probability (DVT in about 28 %), ≤ 1 low (about 6 %).
Frequently asked questions
What Wells score means DVT is likely?
In the two-level version, 2 points or more = DVT likely; 1 point or less = DVT unlikely.
Can a low Wells score exclude DVT without ultrasound?
Only together with a negative D-dimer. In Wells 2003, the D-dimer strategy had a 3-month VTE rate of 0.4 % among patients in whom DVT had been ruled out.
What is the difference between Wells DVT and Wells PE?
They are separate scores with different items and cut-offs. Wells PE uses 1–3-point items and a cut-off of > 4; Wells DVT uses 1-point items and a cut-off of ≥ 2.
Evidence and guidelines
- Primary source: Wells PS et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med 2003;349(13):1227-1235.
- AWMF S2k 065-002 (2023), Tab. 2.1 and Empfehlung 2.2 (Wells-Score, 2-stufige Bewertung).
- Wells PS et al. Does this patient have deep vein thrombosis? JAMA 2006;295(2):199-207.
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