Wells score (deep vein thrombosis)

Pre-test probability of leg DVT (two-level: likely / unlikely)

Sources last checked: 2026-10-13

Wells score (deep vein thrombosis)

Pre-test probability of leg DVT (two-level: likely / unlikely)

0
≤ 1 — DVT unlikely

In the Wells 2003 strategy and AWMF 2023, D-dimer is the next step: a negative result excludes DVT without ultrasound; a positive D-dimer leads to compression ultrasound.

Validated in outpatients with suspected first lower-limb DVT. It performs less well in inpatients, in suspected recurrence and in pregnancy. A three-level version (≤ 0 low, 1–2 moderate, ≥ 3 high) also exists — do not mix the two.

Source: Wells PS et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med 2003;349(13):1227-1235.Open

Interpretation

≤ 1 — DVT unlikelyIn the Wells 2003 strategy and AWMF 2023, D-dimer is the next step: a negative result excludes DVT without ultrasound; a positive D-dimer leads to compression ultrasound.
≥ 2 — DVT likelyIn the Wells 2003 strategy and AWMF 2023, compression ultrasound is the next step; if negative, a negative D-dimer or repeat ultrasound after about a week completes the work-up.

What is the Wells score (deep vein thrombosis)?

The Wells DVT score estimates the probability of lower-limb deep vein thrombosis from nine clinical findings and one subtractive item. In the two-level form used by Wells and colleagues in a randomised management study (NEJM 2003), patients with ≤ 1 point (DVT unlikely) and a negative D-dimer could safely forgo ultrasound. It is the score used in the German AWMF S2k guideline.

When to use it

  • Outpatients or emergency patients with suspected first DVT of the leg.
  • Before ordering D-dimer, to decide whether a negative result can exclude DVT.
  • To prioritise compression ultrasound when access is limited.

When not to use it

  • Suspected upper-limb DVT.
  • Pregnancy and hospitalised patients, where performance is weaker.
  • Suspected recurrent DVT in the same leg without considering prior imaging.

How it is calculated

CriterionPoints
Active cancer (treatment ongoing, within 6 months, or palliative)+1
Paralysis, paresis or recent plaster immobilisation of the leg+1
Bedridden ≥ 3 days, or major surgery within 12 weeks (general or regional anaesthesia)+1
Localised tenderness along the deep venous system+1
Entire leg swollen+1
Calf swelling ≥ 3 cm compared with the asymptomatic side+1
Pitting oedema confined to the symptomatic leg+1
Collateral superficial veins (non-varicose)+1
Previously documented DVT+1
Alternative diagnosis at least as likely as DVT-2

Clinical pearls and limitations

  • Validated in outpatients with suspected first lower-limb DVT. It performs less well in inpatients, in suspected recurrence and in pregnancy. A three-level version (≤ 0 low, 1–2 moderate, ≥ 3 high) also exists — do not mix the two.
  • 'Alternative diagnosis at least as likely' subtracts 2 points — the score can be negative.
  • Calf circumference is measured 10 cm below the tibial tuberosity and compared with the other leg.
  • Active cancer means treatment within 6 months, ongoing treatment, or palliative care.
  • In AWMF 2023, the two-level score: ≥ 2 high probability (DVT in about 28 %), ≤ 1 low (about 6 %).

Frequently asked questions

What Wells score means DVT is likely?

In the two-level version, 2 points or more = DVT likely; 1 point or less = DVT unlikely.

Can a low Wells score exclude DVT without ultrasound?

Only together with a negative D-dimer. In Wells 2003, the D-dimer strategy had a 3-month VTE rate of 0.4 % among patients in whom DVT had been ruled out.

What is the difference between Wells DVT and Wells PE?

They are separate scores with different items and cut-offs. Wells PE uses 1–3-point items and a cut-off of > 4; Wells DVT uses 1-point items and a cut-off of ≥ 2.

Evidence and guidelines

  1. Primary source: Wells PS et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med 2003;349(13):1227-1235.
  2. AWMF S2k 065-002 (2023), Tab. 2.1 and Empfehlung 2.2 (Wells-Score, 2-stufige Bewertung).
  3. Wells PS et al. Does this patient have deep vein thrombosis? JAMA 2006;295(2):199-207.

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