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Estradiol pg/mL → pmol/L

Convert estradiol from pg/mL to pmol/L

Sources last checked: 2026-11-03

Estradiol pg/mL → pmol/L

Convert estradiol from pg/mL to pmol/L

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Converts units only; reference ranges depend on the laboratory, the assay and the patient.

Source: AMA Manual of Style, 11th ed. (Oxford Academic) — Units of measure converter, Table 2: Selected laboratory tests and conversion factors.Open

What is the Estradiol pg/mL → pmol/L?

Oestradiol (E2) is reported in pg/mL in Turkey, the USA and many German and Austrian laboratories, and in pmol/L in the UK and many other European laboratories. This converter multiplies by 3.671, which follows from the molar mass of 17β-oestradiol (272.4 g/mol). It is used in fertility, gynaecological endocrinology and oncology.

When to use it

  • Comparing a pg/mL oestradiol with European fertility or menopause literature in pmol/L
  • Following oestradiol during ovarian stimulation when results come from different laboratories
  • Reading oncology or andrology papers that report pmol/L
  • Exam preparation

When not to use it

  • Ethinylestradiol from combined oral contraceptives — most oestradiol assays do not measure it reliably
  • Oestrone or oestriol, which are different oestrogens with different molar masses
  • Low concentrations measured by direct immunoassay (e.g. men, postmenopausal women, aromatase-inhibitor therapy) without considering assay limitations

How it is calculated

Estradiol (pmol/L) = estradiol (pg/mL) × 3.671

Clinical pearls and limitations

  • Converts units only; reference ranges depend on the laboratory, the assay and the patient.
  • 1 pg/mL = 1 ng/L ≈ 3.671 pmol/L; 80 pg/mL ≈ 294 pmol/L.
  • Direct immunoassays lose precision and specificity at low concentrations; LC-MS/MS is preferred when low values matter.
  • Fulvestrant can cross-react with some oestradiol immunoassays and give falsely high results.
  • Oestradiol varies across the menstrual cycle; reference ranges depend on cycle phase, life stage, assay and laboratory.

Frequently asked questions

How do I convert estradiol from pg/mL to pmol/L?

Multiply by 3.671. For example, 80 pg/mL × 3.671 = 294 pmol/L and 200 pg/mL × 3.671 = 734 pmol/L.

Why is the estradiol factor 3.671?

Oestradiol has a molar mass of 272.4 g/mol. 1 pg/mL is 1000 pg/L, and 1000 ÷ 272.4 = 3.671 pmol/L.

Is pg/mL the same as ng/L?

Yes, 1 pg/mL = 1 ng/L, so values in ng/L convert with the same factor.

Evidence and guidelines

  1. Primary source: AMA Manual of Style, 11th ed. (Oxford Academic) — Units of measure converter, Table 2: Selected laboratory tests and conversion factors.
  2. PubChem compound summary: estradiol (CID 5757), molecular weight 272.4 g/mol.

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For healthcare professionals and medical students. These tools support, and do not replace, clinical judgement. Always check results against the original source and your local protocols.