Digoxin ng/mL → nmol/L

Convert digoxin from ng/mL to nmol/L

Sources last checked: 2026-11-03

Digoxin ng/mL → nmol/L

Convert digoxin from ng/mL to nmol/L

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Converts units only; reference ranges depend on the laboratory, the assay and the patient.

Source: AMA Manual of Style, 11th ed. (Oxford Academic) — Units of measure converter, Table 2: Selected laboratory tests and conversion factors.Open

What is the Digoxin ng/mL → nmol/L?

Serum digoxin is reported in ng/mL (identical to µg/L) by most laboratories, while some laboratories in countries that apply SI units strictly, and part of the pharmacology literature, use nmol/L. This converter multiplies by 1.281, the factor that follows from the molar mass of digoxin (780.9 g/mol).

When to use it

  • Comparing a digoxin level in ng/mL with a guideline, study or poison-centre advice given in nmol/L
  • Documenting therapeutic drug monitoring for a patient transferred between health systems
  • Calculations for digoxin-specific antibody fragments that require a concentration in a particular unit
  • Pharmacology exam questions on therapeutic drug monitoring

When not to use it

  • Digitoxin, which is widely used in German-speaking countries, has a different molar mass and different target concentrations
  • Samples taken before the distribution phase is complete, which overstate the tissue level whatever the unit
  • Total digoxin measured by immunoassay after digoxin-specific antibody fragments have been given

How it is calculated

Digoxin (nmol/L) = digoxin (ng/mL) × 1.281

Clinical pearls and limitations

  • Converts units only; reference ranges depend on the laboratory, the assay and the patient.
  • 1 ng/mL = 1 µg/L = 1.281 nmol/L; conversely 1 nmol/L = 0.7806 ng/mL.
  • Sample after the distribution phase and, for routine monitoring, at steady state; an early post-dose sample can look toxic without reflecting myocardial concentration.
  • Hypokalaemia, hypomagnesaemia, hypercalcaemia and hypothyroidism increase sensitivity to digoxin, and renal impairment raises the level; a value must be read with electrolytes and kidney function.
  • Endogenous digoxin-like immunoreactive substances (e.g. in neonates, pregnancy, renal or liver failure) and some drugs can interfere with immunoassays.

Frequently asked questions

How do I convert digoxin from ng/mL to nmol/L?

Multiply by 1.281. For example, 0.65 ng/mL × 1.281 = 0.83 nmol/L.

Why is the digoxin factor 1.281?

Digoxin has a molar mass of 780.9 g/mol. 1 ng/mL equals 1 µg/L, and 1000 ÷ 780.9 = 1.281 nmol/L.

Is ng/mL the same as µg/L for digoxin?

Yes. 1 ng/mL = 1 µg/L exactly, so a value printed in µg/L can be entered here unchanged as ng/mL.

Can I convert a digitoxin level with this calculator?

No. Digitoxin is a different glycoside with its own molar mass, so this factor does not apply.

Evidence and guidelines

  1. Primary source: AMA Manual of Style, 11th ed. (Oxford Academic) — Units of measure converter, Table 2: Selected laboratory tests and conversion factors.
  2. PubChem compound summary: digoxin (CID 2724385), molecular weight 780.9 g/mol.

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